RT Journal A1 EDES RT T1 THe present relations of psychotherapy JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1909 FD January 9 VO LII IS 2 SP 92 OP 96 DO 10.1001/jama.1909.25420280006002 UL http://dx.doi.org/10.1001/jama.1909.25420280006002 AB The answer to the question whether the pathologist can ever draw a sharp line between organic disease and functional disturbance is yet far off. Newer methods are constantly narrowing the list of maladies of which the organic substratum has been hitherto unknown.Every expenditure of nervous energy, every mental action, every emotion, is undoubtedly accompanied by a subtle change in a larger or smaller group of neurones, some breaking down of the complicated vital molecules into simpler ones more closely akin to the inorganic, more accessible to the microscope and the test-tube. Fatigued tissues can be recognized under the microscope, and when the balance between fatigue and repair is broken for too long a time permanent degeneration is manifest. It is more in accordance with our knowledge of tissue metamorphosis and of toxic action to assume that the material change is the primary one. The rapid action of many poisons