RT Journal A1 Larrey D T1 MUltiple sclerosis and human interferon alfa-reply JF JAMA JO JAMA YR 1989 FD November 17 VO 262 IS 19 SP 2684 OP 2684 DO 10.1001/jama.1989.03430190064029 UL http://dx.doi.org/10.1001/jama.1989.03430190064029 AB In Reply.—  We certainly agree with Dr Coyle that hyperthermia caused by interferon1 is one of the possible mechanisms by which interferon may have induced exacerbation of multiple sclerosis in our patient.