RT Journal
A1 Dalakas M, Wichman A, Sever J
T1 AIds and the nervous system
JF JAMA
JO JAMA
YR 1989
FD April 28
VO 261
IS 16
SP 2396
OP 2399
DO 10.1001/jama.1989.03420160128036
UL http://dx.doi.org/10.1001/jama.1989.03420160128036
AB A SELECTED CASE 
    A 32-YEAR-OLD, healthy homosexual man was found to be seropositive for human immunodeficiency virus (HIV) on routine testing. He was in good general health. His peripheral blood lymphocyte subsets were normal. Eight months later, he noted a gradual onset of weakness and paresthesias in both legs. Weakness progressed, and within a 2-month period he became wheelchair bound. On examination, he had severe, primarily distal muscle weakness with bilateral footdrop and areflexia. Pinprick sensation was diminished below the knees and vibratory and position sensation was absent in his feet. The cerebrospinal fluid (CSF) protein level was increased to 2.12 g/L with pleocytosis. Nerve conduction velocity was slow (averaging 22 m/s), with conduction block consistent with demyelinating polyneuropathy. A sural nerve biopsy specimen showed features of segmental demyelination with perivascular inflammation. Normal results were obtained from blood chemistries, a serum immunoglobulin profile, thyroid studies, and a complete blood cell