RT Journal
A1 Svensson CK
T1 REpresentation of american blacks in clinical trials of new drugs
JF JAMA
JO JAMA
YR 1989
FD January 13
VO 261
IS 2
SP 263
OP 265
DO 10.1001/jama.1989.03420020117041
UL http://dx.doi.org/10.1001/jama.1989.03420020117041
AB Investigations that have revealed racial differences in drug response and disposition indicate the need for adequate representation of racial minorities in clinical drug trials. There is concern, however, that there may be a disproportionate use of racial and ethnic minorities in clinical research due to the inner city location of most university hospitals. To examine this issue, we reviewed the representation of American blacks in 50 recently published clinical trials of new drugs. This survey revealed that investigators do not seem to adequately take into account racial differences as a potential source of variability. It also was found that in the majority of studies, the proportion of black subjects is less than their proportion in the general population. This underrepresentation in clinical trials suggests that insufficient data exist to accurately assess the safety and efficacy of many new drugs in American blacks.(JAMA 1989;261:263-265)