RT Journal A1 Hansell N T1 APproaching long-term neuroleptic treatment of schizophrenia JF JAMA JO JAMA YR 1979 FD September 21 VO 242 IS 12 SP 1293 OP 1294 DO 10.1001/jama.1979.03300120047027 UL http://dx.doi.org/10.1001/jama.1979.03300120047027 AB Neuroleptic therapy can prevent some acute episodes and may improve the level of function in some cases of chronic schizophrenia. The hazards of tardive dyskinesia require a rigorous design for any long-term use of neuroleptics. The protocol includes narrow indications, demonstrations of efficacy and necessity, and arrangements for surveillance, cooperation, and emergency. Patient instruction improves the precision of medication use and may increase adaptive efforts during episodes.(JAMA 242:1293-1294, 1979)