RT Journal
A1 Feldtman RW, Andrassy RJ, Page CP
T1 POvidone iodine skin sensitivity observed with possibly altered immune status
JF JAMA
JO JAMA
YR 1979
FD July 20
VO 242
IS 3
SP 239
OP 239
DO 10.1001/jama.1979.03300030015008
UL http://dx.doi.org/10.1001/jama.1979.03300030015008
AB To the Editor.— 
    We have noted 11 patients who have had their surgical wounds covered with a dressing containing 10% povidone iodine (Betadine). The wounds showed cutaneous erythema, induration, and also papulation, which conformed to the configuration of the dressing. All 11 patients who demonstrated this also showed a similar reaction to a 2×2=cm cotton pledget saturated with 10% povidone iodine. Diagnosis in ten of the 11 patients was suspect for altered immune state.These observations prompted a prospective evaluation of povidone iodine skin sensitivity to confirm our incidental observations and to determine the incidence of skin sensitivity in the population of patients admitted to our surgical service.One hundred sixty-six consecutive patients admitted to the general surgical service were prospectively tested for skin sensitivity to povidone iodine. After we obtained informed consent, a 2×2=cm cotton povidone iodine swab was taped to the medial forearm with a piece of 2=in