RT Journal
A1 Finch WR, Strottman M
T1 ACute adverse reactions to ibuprofen in systemic lupus erythematosus
JF JAMA
JO JAMA
YR 1979
FD June 15
VO 241
IS 24
SP 2616
OP 2618
DO 10.1001/jama.1979.03290500024015
UL http://dx.doi.org/10.1001/jama.1979.03290500024015
AB Three young women with systemic lupus erythematosus who were given ibuprofen for arthritis voluntarily discontinued taking the drug. On reinstitution of therapy, profound hypotension, fever, and headaches developed within hours, without other identifiable cause. A possible relationship to salicylate intolerance was considered. Because of these apparent side effects, we stress caution in the use of ibuprofen in systemic lupus erythematosus, particularly if there is any history of salicylate intolerance.(JAMA 241:2616-2618, 1979)