RT Journal
A1 Murillo J, Standiford HC, Schimpff SC, Tatem BA
T1 GEntamicin and ticarcillin serum levels
JF JAMA
JO JAMA
YR 1979
FD June 1
VO 241
IS 22
SP 2401
OP 2403
DO 10.1001/jama.1979.03290480035020
UL http://dx.doi.org/10.1001/jama.1979.03290480035020
AB Ticarcillin disodium and gentamicin sulfate serum levels were measured one and five hours after intravenous administration. Patients receiving ticarcillin plus gentamicin had a significantly lower mean gentamicin level one and five hours after antibiotic administration than patients receiving cephalothin sodium plus gentamicin. The serum ticarcillin levels were significantly lower five hours after administration in patients receiving ticarcillin plus gentamicin than in those receiving ticarcillin plus cephalothin. Low antibiotic serum levels in patients with serious infections treated with these antibiotic combinations are of potential clinical significance; therefore, to ensure an optimal antimicrobial therapy, it is advisable to determine the drug serum concentrations (especially aminoglycoside) even in patients with normal renal function when treating with combinations of antimicrobials.(JAMA 241:2401-2403, 1979)