RT Journal A1 Klerman GL, Hirschfeld RA T1 MEchanism of sweating from tricyclics-reply JF JAMA JO JAMA YR 1979 FD May 11 VO 241 IS 19 SP 2008 OP 2008 DO 10.1001/jama.1979.03290450014012 UL http://dx.doi.org/10.1001/jama.1979.03290450014012 AB Mr Krick is absolutely correct that hyperhidrosis from the administration of tricyclic antidepressants is a sympathomimetic effect.