RT Journal
A1 Kim Y, Lees D, Lake CR, et al
T1 HYperthermia potentiates doxorubicin-related cardiotoxic effects
JF JAMA
JO JAMA
YR 1979
FD April 27
VO 241
IS 17
SP 1816
OP 1817
DO 10.1001/jama.1979.03290430034020
UL http://dx.doi.org/10.1001/jama.1979.03290430034020
AB The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction. Individually, doxorubicin and hyperthermia were tolerated by the patient without incident. Catecholamine determinations showed that the administration of doxorubicin under hyperthermic conditions increased the liberation of both epinephrine and norepinephrine. The acute synergistic cardiotoxic effects occurred with doxorubicin dosages that were severalfold less than those associated with only mild and transient ECG disturbances under normothermic conditions.(JAMA 241:1816-1817, 1979)