RT Journal
A1 Spiers AD, Neiman RS, Lord KE, Deal DR, Spiers AD, Jr, Schneider LI
T1 CYtogenetics—an aid to histopathology in malignant lymphomas
JF JAMA
JO JAMA
YR 1979
FD March 23
VO 241
IS 12
SP 1227
OP 1228
DO 10.1001/jama.1979.03290380011007
UL http://dx.doi.org/10.1001/jama.1979.03290380011007
AB To the Editor.— 
    Because of their objectivity, cytogenetic studies are a valuable diagnostic aid in leukemias, myeloproliferative syndromes,1 and in suspected malignant effusions2—conditions where diagnosis is cytological, subjective, and often difficult. Malignant lymphomas often present problems of histological diagnosis, but few reports3 describe use of cytogenetics as an aid to histopathology. In two of our patients, malignant lymphoma could not be diagnosed histologically, but the diagnosis was supported by cytogenetic findings; in one case this was borne out by clinical events.Report of Cases.— 
    Case 1.—A 71-year-old man had generalized lymphadenopathy; an inguinal node biopsy specimen was diagnosed as histiocytic lymphoma or malignant histiocytosis. The patient was treated for 13 months with an antineoplastic regimen of cyclophosphamide, vincristine sulfate, prednisone (COP). Afterwards he was well for three years, and then generalized mild lymphadenopathy developed. An axillary node biopsy specimen showed follicular and interfollicular hyperplasia, with numerous