RT Journal
A1 Gryder JW
T1 SAccharin and bladder cancer
JF JAMA
JO JAMA
YR 1979
FD March 9
VO 241
IS 10
SP 997
OP 997
DO 10.1001/jama.1979.03290360012009
UL http://dx.doi.org/10.1001/jama.1979.03290360012009
AB To the Editor.— 
    The many busy physicians who did not have time to study carefully the recent article concerning saccharin and bladder cancer by Kessler and Clark (240:349,1978) may have been misled by the last sentence of the abstract: "It is concluded that neither saccharin nor cyclamate is likely to be carcinogenic in man, at least at the moderate dietary ingestion levels reported by the patient sample."A less subjective and more scientifically satisfying abstract would give a quantitative indication of what is considered "unlikely." The information needed to make such an estimate is contained in Table 11 of the article and is stated in the text: "A 37% increase in bladder cancer risk could have been detected among NNS [nonnutritive sweetener] users with a power of 80%." Another way of defining "unlikely" is shown by Dr Kessler's statement that his study "was not sensitive enough to pick up an