RT Journal
A1 Gerfo P, Colacchio T, Colacchio D, Feind C
T1 THyroglobulin in benign and malignant thyroid disease
JF JAMA
JO JAMA
YR 1979
FD March 2
VO 241
IS 9
SP 923
OP 925
DO 10.1001/jama.1979.03290350043022
UL http://dx.doi.org/10.1001/jama.1979.03290350043022
AB Thyroglobulin (TG) is a 19S glycoprotein produced by normal thyroids and almost all nonmedullary thyroid cancers. Radioimmunoassays measure serum levels of TG, and these levels are abnormally elevated in patients with metastatic thyroid cancer. Data from our study show that TG measurement is not effective in screening high-risk populations for thyroid cancer. Nevertheless, serum TG determinations are useful for assessing the presence and possibly the extent of residual or recurrent nonmedullary thyroid cancer in patients who have undergone total thyroidectomy.(JAMA 241:923-925, 1979)