RT Journal
A1 Senekjian HO, Stinebaugh BJ, Mattioli CA, Suki WN
T1 IRreversible renal failure following vesicoureteral reflux
JF JAMA
JO JAMA
YR 1979
FD January 12
VO 241
IS 2
SP 160
OP 162
DO 10.1001/jama.1979.03290280040025
UL http://dx.doi.org/10.1001/jama.1979.03290280040025
AB Antireflux surgery was performed in five patients with vesicoureteral reflux at a time when renal insufficiency was present. Notable proteinuria was present in four of the patients, and a kidney biopsy specimen showed glomerular lesions in one. Despite the eradication of reflux and of infection, all five patients continued to have progressive renal insufficiency culminating in renal failure. Vesicoureteral reflux nephropathy may include a glomerulopathy leading to progressive glomerular sclerosis. Antireflux surgery would not alter this ongoing process and therefore would not halt progressive renal failure.(JAMA 241:160-162, 1979)