RT Journal
A1 Wolfe RC
T1 REports of propoxyphene dependence
JF JAMA
JO JAMA
YR 1969
FD December 29
VO 210
IS 13
SP 2398
OP 2398
DO 10.1001/jama.1969.03160390060024
UL http://dx.doi.org/10.1001/jama.1969.03160390060024
AB To the Editor:— 
    In a case report by Salguero et al (210:135, 1969) of propoxyphene dependence, the following statement is made: "Almost no data that propoxyphene hydrochloride can produce drug dependence in man are available."It is true that case reports are scanty. I should like to add one reference to those supplied by the authors.Wolfe et al reported a case of propoxyphene addiction and withdrawal syndrome (Ann Intern Med70:773, 1969) with an estimated daily intake of 2,300 mg. The patient was maintained in the hospital on a regimen of 1,300 mg daily. Abrupt discontinuance produced psychic and physical withdrawal syndrome.It would appear that propoxyphene dependence is more frequent than published reports would indicate.