RT Journal
A1 Lucas GJ, Lehrnbecher W
T1 HYdroxyurea in nasopharyngeal cancer
JF JAMA
JO JAMA
YR 1969
FD December 29
VO 210
IS 13
SP 2397
OP 2397
DO 10.1001/jama.1969.03160390059019
UL http://dx.doi.org/10.1001/jama.1969.03160390059019
AB To the Editor:— 
    Due to the anatomic location, malignant nasopharyngeal tumors are frequently silent for some time and are only recognized when they have extended beyond the limit of surgical correction. Hydroxyurea (Hydrea) has been found particularly useful for chemotherapy of head and neck malignancies in combination with irradiation.1,2Report of a Case:— 
    In 1967 a 53-year-old Chinese psychiatric patient (schizophrenic) was noted to have a dense leukoma in the right cornea relative to an ulcer which had been cauterized about five years before. A disturbance in extraocular motility was manifested by sixth nerve palsy bilaterally. Approximately seven months later serosanguineous discharge and difficulty in swallowing occurred. Enlarged lymph nodes over the posterior triangle were noted bilaterally.X-ray films of the sinus and skull revealed marked tumor invasion in the base of the skull and paranasal sinuses, later diagnosed as a poorly differentiated infiltrating squamous cell carcinoma. An extrinsic compression