RT Journal
A1 Kaltreider H, Talal N
T1 BIlateral parotid gland enlargement and hyperlipoproteinemia
JF JAMA
JO JAMA
YR 1969
FD December 15
VO 210
IS 11
SP 2067
OP 2070
DO 10.1001/jama.1969.03160370051010
UL http://dx.doi.org/10.1001/jama.1969.03160370051010
AB Sjögren's syndrome was the initial diagnosis of the physicians who referred five patients with bilateral, noninflammatory parotid gland enlargement. This diagnosis was not confirmed in any case. All five patients had elevated plasma triglyceride concentrations and mild diastolic hypertension. Increased intake of alcoholic beverages, abnormal glucose tolerance, and moderate obesity were frequently present. Massive replacement of the parotid gland tissue by fat was observed in two biopsy specimens. Restriction of calories, alcoholic beverages, and the percent of calories from carbohydrate resulted in regression of parotid gland size in three patients observed for more than three months. A modest short-term reduction in size of the parotid gland occurred in one other patient over a five-week period. Hypertriglyceridemia was also ameliorated by this dietary regimen.