RT Journal A1 Reier CE, Hamelberg W T1 COnscious analgesia and amnesia for cardioversion JF JAMA JO JAMA YR 1969 FD December 15 VO 210 IS 11 SP 2052 OP 2054 DO 10.1001/jama.1969.03160370036006 UL http://dx.doi.org/10.1001/jama.1969.03160370036006 AB Conscious analgesia (stage I, plane 3) produced by the inhalation of methoxyflurane was used in 20 consecutive patients who underwent 22 elective direct-current countershock procedures for supraventricular arrhythmias. After the drug had been administered in concentrations adequate to produce signs of perseveration, loss of memory, delayed response to verbal commands, and inability to focus eyes, the direct-current countershock was delivered. Although the patients responded to verbal commands just prior to the procedure, postoperative interviews revealed complete amnesia. No significant changes in heart rate, blood pressure, or ventilation were noted. Following the procedure, emergence to an alert, oriented state occurred within two to five minutes. The technique provided both analgesia and amnesia—but without general anesthesia.