RT Journal
A1 Ohnuma T, Holland JF, Nagel G, Arneault Gt
T1 EFfects of l-asparaginase in acute myelocytic leukemia
JF JAMA
JO JAMA
YR 1969
FD December 8
VO 210
IS 10
SP 1919
OP 1921
DO 10.1001/jama.1969.03160360065021
UL http://dx.doi.org/10.1001/jama.1969.03160360065021
AB A man with acute myelocytic leukemia was induced into complete remission after a single injection of L-asparaginase 1,000 international units/kg body weight. Nausea, vomiting, fever, weight loss, muscle wasting, hepatic impairment, pancreatitis, hypoinsulinemia, hyperglycemia, fibrinogenopenia, hypocholesterolemia, malabsorption syndrome, and acute brain dysfunctional syndrome developed. These phenomena of L-asparaginase toxicity can be interpreted as induced asparagine deficiency. A "rescue" infusion of L-asparagine was attempted. After relapse eight months later, the patient again attained remission from L-asparaginase.