RT Journal
T1 ABnormal insulin in myocardial infarction
JF JAMA
JO JAMA
YR 1969
FD December 8
VO 210
IS 10
SP 1915
OP 1916
DO 10.1001/jama.1969.03160360061017
UL http://dx.doi.org/10.1001/jama.1969.03160360061017
AB Despite the fact that good, statistically acceptable investigations (Howell and Wilson1 and Paul et al2) have refuted Yudkin's hypothesis, which maintains that high sugar intake is the chief dietary factor in the etiology of coronary heart disease, it is clear that a clinical association does exist between faulty carbohydrate metabolism, abnormal lipid pattern, and myocardial infarction. Chance, Albutt, and Edkins3 demonstrated that total serum lipid was elevated in 64% of patients and serum cholesterol in 43% of a series of untreated diabetic children; abnormal lipoprotein patterns were found in 77% of all juvenile diabetics tested. In another study4 the same authors discovered that a normal lipid pattern could be sustained over a period of ten years in properly treated juvenile diabetics on a standard diabetic diet; those on an unsaturated fatty-acid-rich diet did not fare any better. This implies that other, nondietary factors may be involved