RT Journal
A1 Kuhns LR, Spencer ML, Bacon GE, Lowrey GH
T1 CHlorpropamide-induced hypoglycemia in a child with diabetes insipidus
JF JAMA
JO JAMA
YR 1969
FD November 3
VO 210
IS 5
SP 907
OP 907
DO 10.1001/jama.1969.03160310095030
UL http://dx.doi.org/10.1001/jama.1969.03160310095030
AB To the Editor:— 
    A recent discussion of diabetes insipidus1 indicated that experience to date is limited as to whether or not treatment with chlorpropamide involves a significant hazard from hypoglycemia. The following case report emphasizes the possible dangers of this drug in patients with diabetes insipidus.Report of a Case:— 
    An 11-year-old girl weighing 29 kg (64 lb) had had a craniopharyngioma which was partially removed at the age of 5 years. The patient did well postoperatively except for poor vision secondary to optic nerve damage. Maintenance therapy consisted of thyroid extract, 0.09 gm daily; prednisone, 3 mg daily in divided doses, and vasopressin (Pitressin) tannate in oil, 1 ml every two days. She had been on a similar regimen for six years. During a routine outpatient visit, chlorpropamide treatment, 250 mg twice daily was instituted in an attempt to eliminate the need for vasopressin injections. During the next