RT Journal A1 Parks TD T1 PErfume dermatitis JF JAMA JO JAMA YR 1969 FD October 20 VO 210 IS 3 SP 559 OP 559 DO 10.1001/jama.1969.03160290111043 UL http://dx.doi.org/10.1001/jama.1969.03160290111043 AB To the Editor:—  Drs. Keith, Reich, and Bush (209:269, 1969) reported dermatitis in the anogenital region and coincident use of perfumed toilet paper. They did not conduct patch tests. It seems unlikely that the perfume in toilet paper could cause any effect as all of it reaches the paper by diffusion. The method of perfuming a toilet-paper roll involves placing the perfume on the inner core, not on the paper itself. The amount of perfume thus added amounts to less than 0.02% of the weight of the roll.The high incidence (4%) of patients who reacted to perfumes in patch tests by Rothenborg and Hjorth must be viewed in context.1 All of these subjects were already afflicted with dermatitis. They were challenged with 5% solution of perfume which is about 5 times that found in the usual toilet soap and more than 250 times that added to toilet