RT Journal
A1 Black MB
T1 SErum enzyme values in infectious mononucleosis
JF JAMA
JO JAMA
YR 1969
FD October 20
VO 210
IS 3
SP 559
OP 559
DO 10.1001/jama.1969.03160290111042
UL http://dx.doi.org/10.1001/jama.1969.03160290111042
AB To the Editor:— 
    The dissociation of serum bilirubin concentration and alkaline phosphatase activity described by Shuster and Ognibene (209:267, 1969) has also been noted in this laboratory. Additional information has been obtained with serum transaminase values and lactic dehydrogenase (LDH) levels with isoenzymes.In acute infectious mononucleosis without icterus, the LDH level is consistently elevated (700 to 1400 units) and the alkaline phosphatase activity may rise to 10 Bodansky units. Despite significant hyperbilirubinemia in infectious mononucleosis, the transaminase values are both consistently below 200 units, the alkaline phosphatase activity below 20 units, and the lethal dose (LD5) liver fraction is less than 20%. In infectious hepatitis, the LD5 is more than 50% in almost all cases and the transaminase values numerically approximate the LDH values.