RT Journal T1 HYpoglycemia—hot or cold? JF JAMA JO JAMA YR 1969 FD October 13 VO 210 IS 2 SP 340 OP 340 DO 10.1001/jama.1969.03160280080023 UL http://dx.doi.org/10.1001/jama.1969.03160280080023 AB In 1968, Ramos and his colleagues1 reported in The Journal the occurrence of fever in diabetic patients with insulin-induced hypoglycemia. In the present issue (p 345) the ultimate in paradoxy appears—a study of the frequency of hypothermia in hypoglycemia. These seemingly antithetical responses are probably not a matter of chance. Torrid and frigid hypoglycemia, after all, do not have identical backgrounds or run similar courses.The observations of Ramos et al would indicate that fever in glucopenia is not the rule. Temperatures of more than 100 F (37.8 C) were encomtered in only 14 (19%) of 75 patients admitted to the hospital in severe insulin coma over a period of eight years. There was no evidence of infection, but five patients had convulsions as a possible contributing cause of the temperature elevation. Especially noteworthy was the delayed recovery of these febrile patients despite restoration of blood glucose to normal levels