RT Journal
A1 Green JB
T1 THe colloidal gold test of the spinal fluid
JF JAMA
JO JAMA
YR 1969
FD September 22
VO 209
IS 12
SP 1908
OP 1908
DO 10.1001/jama.1969.03160250064028
UL http://dx.doi.org/10.1001/jama.1969.03160250064028
AB To the Editor:— 
    Nicholas J. Fiumara, MD (Question and Answers, 208:2168, 1969), stated in reply to a question about Lange's colloidal gold test, that it "offers little more in diagnostic help than the total protein test [of cerebrospinal fluid]."This statement may be valid in respect to the diagnosis of neurosyphilis but is incorrect if applied to neurologic diagnosis in general.1 Multiple sclerosis and subacute sclerosing panencephalitis are two diseases often associated with an abnormal gold curve in the presence of a normal cerebrospinal fluid total protein value. In fact, an abnormal gold curve may call attention to these diagnostic possibilities, when they have not been previously suspected. In such cases a sample of cerebrospinal fluid should be sent to a more specialized laboratory which can perform electrophoretic studies.