RT Journal A1 Patton RD, Patten E, Stein E, Damato AN T1 LArge doses of procainamide for paroxysmal ventricular tachycardia JF JAMA JO JAMA YR 1969 FD August 25 VO 209 IS 8 SP 1221 OP 1222 DO 10.1001/jama.1969.03160210053018 UL http://dx.doi.org/10.1001/jama.1969.03160210053018 AB Although recurrent ventricular tachycardia can be controlled in many patients with standard doses of procainamide hydrochloride or quinidine sulfate, the occasional patient with a condition refractory to this therapy has been treated with beta- adrenergic blocking agents, cardiac sympathectomy, or pacemakers. In four patients with refractory ventricular tachycardia, 7.5 to 10.5 gm procainamide hydrochloride successfully controlled the arrhythmia without adverse sequelae. Physicians should consider large doses of procainamide before they utilize more radical therapy.