RT Journal
A1 Kelly S
T1 SHort forearms and a unique d chromosome
JF JAMA
JO JAMA
YR 1969
FD July 21
VO 209
IS 3
SP 418
OP 418
DO 10.1001/jama.1969.03160160054022
UL http://dx.doi.org/10.1001/jama.1969.03160160054022
AB To the Editor:— 
    The karyotype of a 21-year-old female college student with short forearms and a maternal history of two generations (Dr. Mario Montes, personal communication) revealed a chromosome abnormality not heretofore described: A D-like chromosome with satellited prominent short arms was seen in 33 of 35 metaphases (Figure).The variable density of the acetoorcein stain resembled that expected from superimposition of a small acrocentric chromosome with satellites or of satellited isochromosome fragments on the heterochromatic short arms of a D chromosome, following an incomplete break at the centromere. The unmatched chromosome was unlabeled after three hours' exposure to tritiated thymidine, as is the asynchronous early-labeling D3 (15) homologue.1Family studies were not possible; it is uncertain, then, whether the unmatched chromosome is fortuitous or is associated with the history of familial short arms.