RT Journal
A1 Vermillion SE, Sheps SG, Strong CG, Harrison EG, Jr., Hunt JC
T1 EFfect of sodium depletion on renin activity of renal venous plasma in renovascular hypertension
JF JAMA
JO JAMA
YR 1969
FD June 23
VO 208
IS 12
SP 2302
OP 2306
DO 10.1001/jama.1969.03160120026006
UL http://dx.doi.org/10.1001/jama.1969.03160120026006
AB In a patient with renovascular hypertension, renal venous renin-activity determinations were carried out during normal sodium intake, after sodium depletion, and after sodium repletion. When the patient was eating a normal sodium diet, renal venous renin-activity levels failed to lateralize, a finding consistent with the results of isotope renography and two separated renal function studies. However, renal venous renin-activity ratios lateralized (ratios greater than 2:1) to the affected side when the patient's severe sodium depletion lasted for three days. From this finding, it was correctly predicted that relief of hypertension would follow nephrectomy for complete occlusion of a branch artery secondary to fibromuscular dysplasia. Acute sodium depletion increases the diagnostic sensitivity of renal venous renin-activity testing in the determination of functional significance of renovascular lesions in hypertensive patients.