RT Journal
A1 Wallerstein RO, Condit PK, Kasper CK, Brown JW, Morrison FR
T1 STatewide study of chloramphenicol therapy and fatal aplastic anemia
JF JAMA
JO JAMA
YR 1969
FD June 16
VO 208
IS 11
SP 2045
OP 2050
DO 10.1001/jama.1969.03160110017004
UL http://dx.doi.org/10.1001/jama.1969.03160110017004
AB Fatal aplastic anemia is a rare disorder, occurring in two per million population each year. Death usually follows overwhelming infection or hemorrhage, or both. The course from onset of anemia to death is often only a few months. Fatal aplastic anemia appeared to be 13 times more frequent after the use of chloramphenicol. Anemia may not appear until the second or even third course of chloramphenicol therapy, and it is not related to dosage.