RT Journal
A1 Oates JA
T1 DRug-drug interaction
JF JAMA
JO JAMA
YR 1969
FD June 9
VO 208
IS 10
SP 1898
OP 1898
DO 10.1001/jama.1969.03160100088017
UL http://dx.doi.org/10.1001/jama.1969.03160100088017
AB Interference With the Delivery of Drugs to Their Sites of Action 
    An increasing number of mechanisms have been described whereby one drug can modify profoundly the action of another. In some of these interactions, the therapeutic effect of a drug may be blocked when another agent prevents it from reaching the site of its pharmacologic action.Interference With Absorption.— 
    One mechanism for interference with the absorption of drugs is illustrated in the study by Northcutt et al in this issue (p 1852), which demonstrates that absorption of orally administered thyroxine and liothyronine (triiodothyronine) by humans is prevented by the anion exchange resin, cholestyramine, which binds these drugs in the intestinal tract. This is an example of the general phenomenon of drug binding by this resin. In experimental animals, cholestyramine has been found to impair the absorption of other drugs including digitoxin, aspirin, secobarbital, and phenylbutazone. It would be valuable to