RT Journal
T1 COrticosteroids in bronchiolitis
JF JAMA
JO JAMA
YR 1969
FD May 12
VO 208
IS 6
SP 1016
OP 1017
DO 10.1001/jama.1969.03160060086014
UL http://dx.doi.org/10.1001/jama.1969.03160060086014
AB Acute bronchiolitis is a viral disease that occurs sporadically in infants and children, twice as often in males as in females. Its incidence is often highest when other viral infections are prevalent in the community, but it is no more prevalent among allergic patients or those with a history of allergy than among other patients.Corticosteroids have been used in the treatment of bronchiolitis to reduce its severity by reducing inflammation in the lungs. However, conclusions drawn from reports of controlled studies of the disease differ on the therapeutic results obtained with corticosteroids. Because the disease is not as common as other viral infections of the respiratory tract, previous studies were limited to the treatment of relatively few patients with small doses of corticosteroids.To evaluate efficacy and safety of corticosteroids in bronchiolitis, Leer et al undertook a double-blind, collaborative study of 297 infants and children at five medical centers across the country, as reported