RT Journal
A1 Swisher CN
T1 COmbination therapy of malaria
JF JAMA
JO JAMA
YR 1969
FD April 28
VO 208
IS 4
SP 695
OP 695
DO 10.1001/jama.1969.03160040103024
UL http://dx.doi.org/10.1001/jama.1969.03160040103024
AB To the Editor:— 
    The recent preliminary communication by Berman (207:128, 1969) suggests that the chloroquine-pyrimethamine-sulfisoxazole therapy reigmen for Plasmodium falciparum malaria should be given wider use as an alternative to the presently advocated quininepyrimethamine regimen. He supports this thesis with data showing a more rapid reduction in fever duration and no increase in recurrence rate with the chloroquine treatment.I have recently reviewed the records of 160 patients following the chloroquine regimen and 250 patients following the quinine regimen during July through October 1968. Both groups were similar in age, race, and location of duty in South Vietnam, and cases were uncomplicated by P vivax or other medical or surgical conditions.In the two groups studied, I found no significant difference in time of onset of illness to time of treatment, duration of fever, or duration of symptoms. Although as Berman states, time of medication is six days for