RT Journal
A1 Lee TC, Lowenfels AN, Rohmans MM
T1 LOcal injection of fluorouracil in skin cancer
JF JAMA
JO JAMA
YR 1969
FD April 21
VO 208
IS 3
SP 536
OP 536
DO 10.1001/jama.1969.03160030110027
UL http://dx.doi.org/10.1001/jama.1969.03160030110027
AB To the Editor:— 
    A recent question in The Journal (207:959, 1969) concerned the use of fluorouracil by local application. We wish to report a favorable experience with local injection of this compound into a recurrent rectal carcinoma.Report of a Case:— 
    A 61-year-old man entered our hospital two years after abdominoperineal resection for adenocarcinoma of the rectum. At the time of readmission he had a friable, painful recurrence in the perineal scar plus demonstrable but asymptomatic pulmonary metastases. The patient was unable to lie supine or walk because of the painful perineal masses (Fig 1).Over a three-month period the patient received treatment with fluorouracil by direct injection into the tumor area. He received a dose of 7.5 mg/kg of drug per injection and the treatments were performed at ten-day intervals. The total course of therapy consisted of ten injections.The patient experienced subjective and objective improvement. The tumor