RT Journal
A1 McCollum RW
T1 VIral hepatitis
JF JAMA
JO JAMA
YR 1969
FD April 21
VO 208
IS 3
SP 524
OP 524
DO 10.1001/jama.1969.03160030098014
UL http://dx.doi.org/10.1001/jama.1969.03160030098014
AB Viral hepatitis 
    Viral hepatitis continues to present a vast array of important, intriguing, and perplexing questions. This situation is not likely to change drastically until specific virologic and serologic methods of study are readily available. Knowledge of the etiologic agents of the two forms, infectious (IH) and serum (SH) hepatitis, has been derived largely from controlled human transmission studies which, in turn, have provided for the systematic observation of epidemiologic and clinical features as well as the collection and preservation of serial serum specimens to serve as invaluable reference materials in the future.The clinical similarity of IH and SH offers a major problem in accurate differential diagnosis. The etiologic agents may be closely related but they are antigenically distinct. They may also differ significantly in their immunogenicity. There is ample evidence, both direct and indirect, in support of a specific immune response following IH infection, eg, direct homologous rechallenge in