RT Journal
A1 Jay B, Blach RK, Wells RS
T1 EYe changes in ichthyosis
JF JAMA
JO JAMA
YR 1969
FD April 7
VO 208
IS 1
SP 155
OP 155
DO 10.1001/jama.1969.03160010151038
UL http://dx.doi.org/10.1001/jama.1969.03160010151038
AB To the Editor:— 
    We read the report by Sever et al (206:2283, 1968), "Eye Changes in Ichthyosis," with great interest and were pleased to see that the authors results agreed, in the main, with ours (Brit J Ophthal52:217, 1968). The characteristic deep-corneal changes of sex-linked (ie, X-linked) ichthyosis were found in 13 of our 26 patients, being uncommon under the age of 10 years and invariably present over the age of 25 years. We found similar changes in three out of 22 patients with the autosomal-dominant ichthyosis vulgaris.We were particularly interested in their observations of the mild corneal changes in the female carrier state of sex-linked ichthyosis. We examined a few females who must have been carriers and, not finding any corneal changes, did not pursue the matter further. We are reviewing our carrier females in order to confirm this most interesting finding.