RT Journal
A1 Starr P
T1 THyroid hormones and protein-bound iodine
JF JAMA
JO JAMA
YR 1969
FD March 3
VO 207
IS 9
SP 1717
OP 1718
DO 10.1001/jama.1969.03150220133029
UL http://dx.doi.org/10.1001/jama.1969.03150220133029
AB To the Editor:— 
    My statement in my letter of July 1968, that triiodothyronine "stimulates metabolism without representation in the PBI value" is supported by the following clinical facts. When one administers 50μg to 100μg of triiodothyronine by mouth daily to a patient who has a normal protein bound iodine value, this protein bound iodine rapidly decreases to an irreducible value; in other words, if clinically significant amounts of triiodothyronine are administered, a patient's PBI level goes down. It does not go up. This, in the face of the fact which Dr. Wiener states, namely, that the concentration of triiodothyronine in the blood is very low; in fact, it is not great enough to make a clinically significant variation in the serum protein bound iodine which is being interpreted by the physician.The second example supporting my statement is that we have administered as much as 0.3 mg of triiodothyronine daily