RT Journal
A1 Valenti C, Schutta EJ, Kehaty T
T1 CYtogenetic diagnosis of down's syndrome in utero
JF JAMA
JO JAMA
YR 1969
FD February 24
VO 207
IS 8
SP 1513
OP 1515
DO 10.1001/jama.1969.03150210097018
UL http://dx.doi.org/10.1001/jama.1969.03150210097018
AB Fetal cells, obtained by amniocentesis from a balanced carrier of D/G chromosome translocation during the 18th week of pregnancy, were analyzed after 22 days of cultivation in vitro. The karyotypes showed a modal chromosome number of 46, with the D/G fusion chromosome characteristic of Down's syndrome. Pregnancy was interrupted by intra-amniotic instillation of hypertonic saline solution. A 700-gm, macerated, male fetus was delivered and showed dermatoglyphic and anatomic changes compatible with the diagnosis made prenatally.