RT Journal
T1 MEdical news
JF JAMA
JO JAMA
YR 1969
FD February 17
VO 207
IS 7
SP 1267
OP 1284
DO 10.1001/jama.1969.03150200033003
UL http://dx.doi.org/10.1001/jama.1969.03150200033003
AB Hemophilia Treated With Spleen Cells 
    Spleen cell infusions have been used to treat severe hemophilia in six patients. The results are promising, according to California investigators."There was a reduction in bleeding episodes and demonstrable rises in factors VIII and IX," says R.G. Desai, MD. He is chief of hematology at Orange County Medical Center, and assistant professor of medicine, University of California at Irvine.The increased levels of factors VIII and IX have persisted for periods up to nine months—the longest follow-up at the time Dr. Desai and his co-workers reported their results to the Western Section meeting of the American Federation for Clinical Research.Of the patients, four had factor VIII deficiency (hemophilia A), one had factor IX deficiency (hemophilia B), and one had Von Willebrand's disease.All but the patient with Von Willebrand's disease had pretreatment levels of factor VIII or IX of less than 1%