RT Journal
A1 Kater RH, Tobon F, Iber FL
T1 INcreased rate of tolbutamide metabolism in alcoholic patients
JF JAMA
JO JAMA
YR 1969
FD January 13
VO 207
IS 2
SP 363
OP 365
DO 10.1001/jama.1969.03150150075025
UL http://dx.doi.org/10.1001/jama.1969.03150150075025
AB In a controlled human study the biological half-life of tolbutamide was found to be reduced more than twofold in alcoholic patients. We suggest that this effect is the result of stimulation by alcohol of a hepatic microsomal enzyme system in the human liver responsible for the metabolism of tolbutamide. The metabolism of other therapeutic agents could be similarly affected by alcohol, and this might lead to irregularities in response to drug treatment.