RT Journal
A1 Close A
T1 PHentolamine hydrochloride in prevention of cutaneous necrosis due to levarterenol
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1959
FD August 15
VO 170
IS 16
SP 1916
OP 1917
DO 10.1001/jama.1959.03010160032009
UL http://dx.doi.org/10.1001/jama.1959.03010160032009
AB It is reasonable to assume that the mechanism by which phentolamine reverses the ischemia associated with extravasation or tissue diffusion of levarterenol is through blockage of action by the latter on adrenergic effector cells. Accumulated evidence indicates that cutaneous necrosis is a preventable complication of levarterenol administration if careful observation for ischemic areas is carried out in all patients who have received levarterenol, with prompt institution of prophylactic instillation of phentolamine when indicated.