RT Journal
A1 Bierman EO
T1 SPontaneous regression of malignant disease
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1959
FD August 8
VO 170
IS 15
SP 1842
OP 1842
DO 10.1001/jama.1959.03010150086022
UL http://dx.doi.org/10.1001/jama.1959.03010150086022
AB To the Editor:— 
    Your guest editorial on spontaneous regression of malignant disease, in The Journal, April 11, page 1758, stated that the theory for spontaneous regression of malignant tumors had not been advanced. The theory for disappearance can be evolved from the research work of biochemists Dulkin and Lobstein of the Research Foundation for Diseases of the Eye. They found that lysozyme, an enzyme found in body fluids and in tears, in addition to being bacteriostatic, is carcinostatic for certain tumors in rats. The work, which resembles Fleming's experiments with penicillin in the manner of procedure, is promising. Clinical trials have not been made.Other body enzymes may also be carcinostatic. Experiments are planned to determine whether lens epithelium secretes carcinostatic substances. Cancer has not been reported in the lens. The progress of cancer is like that of other diseases—a struggle between host resistance and the virulence and degree of