RT Journal
A1 Herting RL, Lees B, Zimmermann AJ, Berryman GH
T1 RIstocetin—a statistical review of three hundred thirty-three cases
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1959
FD May 9
VO 170
IS 2
SP 176
OP 178
DO 10.1001/jama.1959.03010020034010
UL http://dx.doi.org/10.1001/jama.1959.03010020034010
AB Reports received by a manufacturer from physicians using ristocetin, a new antibiotic, were collated with reports published in clinical literature, and the results were analyzed. Among the total of 333 cases in which the drug was used, there were 126 cases of pneumonia, and approximately 70% of these were caused by staphylococci. There were 46 cases of subacute bacterial endocarditis, and approximately 50% of these were caused by staphylococci. The drug was given either by intravenous injection or prolonged intravenous infusion. The most frequent side-effects were thrombophlebitis (20 cases, 6% of the total) and neutropenia (18 cases, 5.4%). Side-effects were absent in 258 (77.5%) of the patients. The side-effects were most frequent in patients receiving the larger doses, and on the basis of these findings it is recommended that the dosage of this antibiotic in adult patients should not normally exceed 2 Gm. per day. Approximately 60% of the patients were completely cured.