RT Journal
A1 Doshay LJ, Constable K
T1 TReatment of paralysis agitans with chlorphenoxamine hydrochloride
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1959
FD May 2
VO 170
IS 1
SP 37
OP 41
DO 10.1001/jama.1959.03010010039008
UL http://dx.doi.org/10.1001/jama.1959.03010010039008
AB Chlorphenoxamine was administered to 25 patients with paralysis agitans in a preliminary test to determine dosage and observe side-reactions. Thereafter it was administered to 136 patients who had been treated unsuccessfully with other drugs. It allayed tremor only in the occasional patient, and in some the tremor was accentuated. Its most consistent effect was on akinetic, tired, weak patients, who were enabled to move with greater celerity, strength, and endurance. It stimulated without inducing excitement and relaxed without causing flaccidity or enfeeblement. Three case histories illustrate its effects on the disabling symptoms of the patient. The side-effects observed were neither frequent nor serious. Tolerance did not seem to increase with lapse of time, and the favorable effects continued only as long as the drug was administered.