RT Journal
A1 Grossman MI
T1 EXperimental pancreatitis—recent contributions
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1959
FD April 4
VO 169
IS 14
SP 1567
OP 1570
DO 10.1001/jama.1959.03000310019003
UL http://dx.doi.org/10.1001/jama.1959.03000310019003
AB The fact that pancreatitis and disease of the biliary tract frequently occur together has led to many types of experiment on possible interactions between bile and pancreatic juice. Especially tempting is the hypothesis that some constituent in bile, in tissue juices, or in inflammatory exudates is capable of activating pancreatic juice and so causing the familiar picture of hemorrhagic necrosis of the pancreas. There is also a tendency to assume that the appearance of abnormal enzymes in the circulation during pancreatitis means that they were produced in the pancreas and are responsible for the symptoms of shock. In reality, the injurious factor in pancreatitis has not yet been identified, and the role played by circulating proteases remains to be explained.