RT Journal
A1 Knights EM, Jr., Brush JS, Schroeder J
T1 SImplified screening test for cystic fibrosis of the pancreas
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1959
FD March 21
VO 169
IS 12
SP 1279
OP 1280
DO 10.1001/jama.1959.03000290005002
UL http://dx.doi.org/10.1001/jama.1959.03000290005002
AB A test paper has been devised for use in quick examination of large numbers of people to detect increased concentrations of chloride in the sweat. The paper is impregnated with silver chromate, which is red. Upon contact with a solution of sodium chloride the red color is replaced by the white color of silver chloride. The paper was found easy to prepare, store, and apply, and after use it could be kept with the records of the case. Used in 91 healthy subjects and 9 patients known to have cystic fibrosis of the pancreas, it gave 3+ reactions with all the latter group. False-positive results were obtained in some children with fever or under emotional stress. Relatively strong (2+) reactions were obtained in some parents of children with cystic fibrosis, which is known to be inheritable.