RT Journal
A1 Hollister LE
T1 CHlorpromazine jaundice
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1959
FD March 14
VO 169
IS 11
SP 1235
OP 1236
DO 10.1001/jama.1959.03000280087020
UL http://dx.doi.org/10.1001/jama.1959.03000280087020
AB To the Editor:— 
    I wrote a report on chlorpromazine jaundice, more than two years ago, based on 17 cases (Hollister, Am. J. Med.23:870, 1957); since that time I have seen only one other case. This declining prevalence of jaundice has also been noted by another observer (Pollack, Am. J. Psychiat.113:1115, 1957). To provide further information, questionnaires were sent to 67 psychiatrists and mental hospitals using or investigating tranquilizing drugs; 45 replies were received, providing the following data.In the year preceding the inquiry, 25 of the respondents had encountered at least one case of chlorpromazine jaundice, while 20 had encountered none. Eighty-seven cases of jaundice were reported by these 25 sources, the largest single series being 13 cases. Data were sometimes incomplete in regard to the number of patients treated for the first time with chlorpromazine during the same period. Available data showed that 70 cases