RT Journal
T1 THe nephrotic syndrome
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1959
FD February 21
VO 169
IS 8
SP 846
OP 846
DO 10.1001/jama.1959.03000250064014
UL http://dx.doi.org/10.1001/jama.1959.03000250064014
AB ACCORDING to Kark and co-workers1 "the metabolic, nutritional and clinical consequences of continued massive albuminuria constitute the nephrotic syndrome." Far from being a single entity, as once thought, it can be produced by a variety of causes which may be grouped as (1) heredofamilial diseases, (2) infections, (3) toxins, (4) allergens, (5) mechanical disturbances, (6) generalized diseases, and (7) intrinsic renal diseases. Pathologically the characteristic lesion is necrosis of the tubules. Clinically the disease is characterized by oliguria, edema, and anorexia, although in many persons it may exist in a subclinical form and be discovered only by a routine urinalysis. In microscopic section the glomeruli may appear to be ischemic, but no change in their structure is seen with the ordinary microscope.2 Folli and co-workers3 studied renal biopsy specimens from patients with the nephrotic syndrome by means of an electron microscope. When their first specimen was taken