RT Journal
A1 CRAWFORD G, LUIKART RH, II
T1 SEvere erythema multiforme with intestinal involvement
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1949
FD July 2
VO 140
IS 9
SP 780
OP 781
DO 10.1001/jama.1949.82900440003006a
UL http://dx.doi.org/10.1001/jama.1949.82900440003006a
AB Under various names (severe erythema multiforme, Stevens-Johnson's disease, erythema multiforme exudativum and ectodermosis erosiva pluriorificialis), the literature indicates infrequent involvement of the alimentary canal in the toxic eruption commonly known as erythema multiforme. In 1874 Hebra1 reported a patient with "erythema gyratum" in whom the autopsy revealed "... in the small bowels similar red circles as on the skin." In 1895, 1900 and 1904, Osler2 published groups of cases, totaling 29, the disease in which he first described as erythema multiforme. In several of these cases there were signs and symptoms referable to the alimentary canal. However, in 1914 Osler3 revised his view in an article referring to most of these cases as examples of Henoch's and Schönlein's purpura. Lever4 and Costello5 each published reviews and case studies in more recent years. Of Lever's 2 patients, neither had signs or symptoms of lesions in the gastrointestinal