RT Journal
A1 WILLIAMS RH
T1 SElection of therapy for individual patients with thyrotoxicosis
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1949
FD April 16
VO 139
IS 16
SP 1064
OP 1068
DO 10.1001/jama.1949.02900330016006
UL http://dx.doi.org/10.1001/jama.1949.02900330016006
AB The obscurity of the causation of thyrotoxicosis and the lack of completely satisfactory results with any type of therapy that has been prescribed for it have promoted continuous investigations, involving many different approaches. Some of the many types of treatment that have been, or are being, investigated are listed in table 1. The rationale of these therapies is based on the hypothesis that the central nervous system plays an important role in regulating the production and release of thyrotropin, which, in turn, governs the production of thyroid hormone; since too much of the latter causes thyrotoxicosis, anything, no matter where its action is centered, which tends to decrease the production of the thyroid hormone or antagonize its action will cause a remissioin in thyrotoxicosis.During approximately the last five years I have investigated various of these types of therapy in 441 patients with thyrotoxicosis. Some of the specific compounds tested