RT Journal
A1 JACOBSEN E, MARTENSEN-LARSEN OO
T1 TReatment of alcoholism with tetraethylthiuram disulfide (antabus®)
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1949
FD April 2
VO 139
IS 14
SP 918
OP 922
DO 10.1001/jama.1949.02900310022006
UL http://dx.doi.org/10.1001/jama.1949.02900310022006
AB During some experiments performed with tetraethylthiuram disulfide (antabus®) in the laboratory, Dr. Jens Hald and one of us (E. J.) discovered that persons who have ingested this substance showed symptoms after consumption of alcohol which differed quantitatively and qualitatively from the common picture of alcoholic intoxication. The discomfort after alcohol consumption in persons treated with tetraethylthiuram disulfide was so intense that we decided to submit this drug to trial as a remedy for alcoholism. The clinical experiments were conducted by one of us (O. M.-L.). The present report includes a short review of the results obtained in the investigations on the biochemical mechanism of this effect and of the clinical results on 100 persons with alcoholism who were treated for six to twelve months.PHARMACOLOGIC CONSIDERATIONS 
    Tetraethylthiuram disulfide is a white, or slightly yellow, powder which is insoluble in water. It is relatively nontoxic. The fatal dose is 2 to